一、导师基本情况

姓名：王永杰，理学博士，副教授，硕士生导师

邮箱：wangyongjie@hznu.edu.cn

ORCID: https://orcid.org/0000-0002-0306-3088

指导专业：药学

二、研究领域

1, 慢性痛的中枢神经调节机制及其药物研发;

2, 神经-肿瘤互作及其药物研发。

三、主讲课程

1. 肿瘤药理学

2. 医学神经生物学实验原理和技术

3. 神经退行性疾病基础和临床

4. 走进恶性肿瘤

5. 生理学

6. 药理学实验

四、教育和工作经历

2005年9月--2009年6月， 哈尔滨工业大学，工学学士

2009年9月--2012年6月， 国家海洋局第一海洋研究所，理学硕士

2013年9月--2017年12月，西安交通大学，理学博士

2020年2月--至今，       杭州师范大学药学院，副教授

五、主持教学科研项目

1. 国家自然科学基金委青年项目：前扣带皮层α2A肾上腺素受体调节自发痛的神经环路研究(81801102)。

2. 国家自然科学基金委面上项目：基于单细胞测序解析APR3通过介导前扣带皮层兴奋性神经元LTP的形成调节神经病理性痛的机制研究(82071230)。

3. 浙江省自然科学基金项目：外侧隔核-背侧导水管周围灰质神经环路调控榄香烯注射液所致化疗痛的机制研究(LY23H090001)。

4. 浙江省医药卫生科技计划项目：牛磺鹅去氧胆酸通过HMGCS1-YAP信号通路抑制胶质母细胞瘤进展(2023RC074)。

5. 浙江省医药卫生科技计划项目：小胶质细胞特异性表达的 MS4A6A 参与胶质母细胞瘤进展(2024KY242)。

六、代表性论著

[1]     Furui Liu, Ziwan He, and Yongjie Wang. "Neural mechanisms, influencing factors and interventions in empathic pain." Neuropharmacology (2025): 110349.

[2]     Wang Qian, Xiumin Xue, Zhichao Chen, Wei Zhang, Yiming Qian, Danni Chen, Lin Lin,Yinfeng Yuan, Weiqiao Zhao, Zhihui Huang* and Yongjie Wang*. "Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway." Molecular Medicine 31.1 (2025): 13.

[3]     Yifan Li, Shufan Ding, and Yongjie Wang*. "Targeting the cholinergic anti-inflammatory pathway: an innovative strategy for treating diseases." Molecular Biology Reports 52.1 (2025): 1-15.

[4]     Linsen Lou, Liujing Zhou, and Yongjie Wang*. "Gut Microbiota: A Modulator and Therapeutic Target for Chronic Pain." Molecular Neurobiology (2024): 1-16.

[5]     Wenhao Lv, Yongjie Wang*. Neural Influences on Tumor Progression within the Central Nervous System. CNS Neuroscience & Therapeutics. 30.10 (2024): e70097.

[6]     Shufan Ding, Yifan Li, Zhichao Chen, Jingnan Hu, Jiayi Li, Junlan Li and Yongjie Wang*. Solanesol Ameliorates Anxiety-like Behaviors via the Downregulation of Cingulate T Cell-Restricted Intracellular Antigen-1 in a Complete Freund’s Adjuvant-Induced Mouse Model. International Journal Of Molecular Sciences. 25.18 (2024): 10165.

[7]     Lin Lin, Yinfeng Yuan, Zhihui Huang*, Yongjie Wang*. YAP Signaling in Glia: Pivotal Roles in Neurological Development, Regeneration and Diseases. Neuroscience Bulletin, (2024): 1-19.

[8]     Danni Chen, Yinfeng Yuan, Zhihui Huang^*, Yongjie Wang^*. LH-Nts neurons regulate VTA calcium dynamics via releasing GABA and NTs. Neuroscience Bulletin, 2024, 40(4): 550-552.

[9]     Shanshan Sun^†, Jiayun Xu^†, Lin Lin^†, Mengxian Jia, Xiumin Xue, Qian Wang, Danni Chen, Zhihui Huang^*, Yongjie Wang^*. Chemotherapeutic drug elemene induces pain and anxiety-like behaviors by activating GABAergic neurons in the lateral septum of mice. Biochemical and Biophysical Research Communications. 2024, 699: 149548.

[10]   Cheng Wu^†, Hui-Fang Shang^†, Yong-Jie Wang^†, Jing-Hua Wang, Zhen-Xing Zuo, Yan-Na Lian, Li Liu, Chen Zhang, Xiang-Yao Li*. Cingulate protein arginine methyltransferases 1 regulates peripheral hypersensitivity via fragile X mental retardation protein. Frontiers in Molecular Neuroscience. 2023, 16: 1153870. (^†co-first author)

[11]   Qian Zhang^†, Yongjie Wang^†, Jie Tao, Ruixue Xia, Yijie Zhang, Yunbin Zhang*, Zhirui Liu*, Jiwei Cheng*. Sex Biased Single Cell Genetic Landscape in Prenatal Mice with Autism Spectrum Disorder. Journal of Genetics and Genomics. 2023, 51(3): 338-351. (^†co-first author)

[12]   Wenhao Lv, Shengyan Lin, Zhenxing Zuo, Zhihui Huang, Yongjie Wang*. Involvement of microglia‐expressed MS4A6A in the onset of glioblastoma. European Journal of Neuroscience. 2024, 59(10): 2836-2849.

[13]   Xiaowu Lin, Zhihui Huang*, Yongjie Wang*. Neuronal mechanisms govern glioblastoma cell invasion. Neuroscience Bulletin. 2023, 39(6):1027–1030

[14]   Zhichao Chen, Qian Wang, Xiumin Xue, Zhihui Huang*, Yongjie Wang*. The neural connections of oxytocin-mediated parental behavior in male mice. 2023, 16: 1091139. Frontiers in Molecular Neuroscience.

[15]   Lin Lin, Xiumin Xue, Zhihui Huang*, Yongjie Wang*. Sodium-calcium exchanger-3 plays critical roles in pain ‘‘wind-up’’. Neuroscience Bulletin, 2023, 39(5): 869-872.

[16]   Xiumin Xue, Qian Wang, Zhihui Huang*, Yongjie Wang*. An empathic pain-regulated neural circuit. Neuroscience Bulletin, 2022, 38(12): 1613-1616.

[17]   Wang Qian, Xue Xiumin, Huang Zhihui* & Wang Yongjie*. Microglia Share the Burden. Neuroscience Bulletin, 2022, 38(6): 695-698.

[18]   Shanshan Sun, Jiali Shi, Xin Wang, Changgang Huang, Yuqian Huang, Jiayun Xu, Yuanyuan Jiang, Liying Cao, Tian Xie*, Yongjie Wang*, Zhihui Huang*. Atractylon inhibits the tumorigenesis of glioblastoma through SIRT3 signaling[J]. American Journal of Cancer Research, 2022, 12(5): 2310-2322.

[19]   Jiali Shi; Shanshan Sun; Shuqiao Xing; Changgang Huang; Yuqian Huang; Qian Wang; Xiumin Xue; Zhichao Chen; Yongjie Wang*; Zhihui Huang*. Fraxinellone inhibits progression of glioblastoma via regulating the SIRT3 signaling pathway. Biomedicine & Pharmacotherapy, 2022, 153(113416).

[20]   Fang Xin, Wang Yongjie*, Huang Zhihui*. Oxytocin Neurons Are Essential in the Social Transmission of Maternal Behavior[J]. Frontiers in Behavioral Neuroscience, 2022, 16: 847396.

[21]   Wang Yongjie, Zuo Zhenxing, WU Cheng, et al. Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral nerve Injury[J]. Frontiers in Molecular Neuroscience, 2017, 10: 289.

[22]   Wang Yongjie, Zuo Zhenxing, Zhang Mei, et al. The Analgesic Effects of (5R, 6R) 6-(3-Propylthio-1, 2, 5-thiadiazol-4-yl)-1-azabicyclo [3.2.1] Octane on a Mouse Model of Neuropathic Pain[J]. Anesthesia and analgesia, 2017, 124(4): 1330.

[23]   Wang Yongjie, Liu Minggang, Wang Jinghua, Cao Wei, Wu, Cheng, ... & Li, Xiangyao (2020). Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity. Cell Reports, 33(6), 108369.

[24]   Wang, Yongjie, and Zhihui Huang. Microglia Interact with Neurons by Forming Somatic Junctions. Neuroscience Bulletin, 36 (2020): 1085-1088.

[25]   Tian, Yonglu*, Yang, Chaojuan*, Cui, Yaxuan*, Su, Feng*, Wang, Yongjie *, Wang, Yangzhen*, ... & Chen Zhang. (2018). An excitatory neural assembly encodes short-term memory in the prefrontal cortex. Cell reports, 22(7), 1734-1744.

[26]   Zuo Zhenxing*, Wang Yongjie*, Liu Li, et al. Huperzine A alleviates mechanical allodynia but not spontaneous pain via muscarinic acetylcholine receptors in mice[J]. Neural plasticity, 2015, 2015.