一、导师基本情况
姓名：王永杰，理学博士，副教授（硕士生导师）
邮箱：wangyongjie@hznu.edu.cn.
指导专业（按照招生目录上的名称填写）：药学、生理学
二、研究领域
1. 研究中枢神经系统中的免疫细胞包括小胶质细胞及巨噬细胞对胶质瘤发生发展的影响；
2. 慢性炎症痛或神经病理性痛等神经系统疾病的调节机制；
3. 利用光遗传或者化学遗传研究胶质细胞包括星形胶质细胞、小胶质细胞或雪旺细胞对肿瘤的影响。
三、主讲课程
1. 肿瘤药理学
2. 医学神经生物学实验原理和技术
3. 神经退行性疾病基础和临床
4. 走进恶性肿瘤
四、教育和工作经历
2005年9月--2009年6月， 哈尔滨工业大学，工学学士
2009年9月--2012年6月， 国家海洋局第一海洋研究所，理学硕士
2013年9月--2017年12月，西安交通大学，理学博士
2020年2月，杭州师范大学药学院，副教授
五、主持教学科研项目（省部级以上）
1. 国家自然科学基金面上项目，基于单细胞测序解析APR3通过介导前扣带皮层兴奋性神经元LTP的形成调节神经病理性痛的机制研究，55万元，2021.01–2024.12。
2. 国家自然科学基金青年项目，前扣带皮层α2A肾上腺素受体调节自发痛的神经环路研究，21万元，2019.01–2021.12。
六、代表性论著
Qian Wang, Xiumin Xue, Zhihui Huang#, Yongjie Wang#. Microglia Share the Burden. Neuroscience Bulletin. (Accepted. #Correspondence author)
Shanshan Sun*, Jiali Shi*, Xin Wang, Changgang Huang, Yuqian Huang, Jiayun Xu, Yuanyuan Jiang, Liying Cao, Tian Xie#, Yongjie Wang#, Zhihui Huang#. Atractylon Inhibits the Tumorigenesis of Glioblastoma through SIRT3 Signaling. American Journal of Cancer Research. (Accepted. #Correspondence author)
Fang, Xin, Yongjie Wang#, and Zhihui Huang#. Oxytocin Neurons Are Essential in the Social Transmission of Maternal Behavior. Frontiers in Behavioral Neuroscience 16 (2022). (#Correspondence author)
Wang YJ, Zuo ZX, WU C, et al. Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral nerve Injury[J]. Frontiers in Molecular Neuroscience, 2017, 10: 289.
Wang YJ, Zuo ZX, Zhang M, et al. The Analgesic Effects of (5R, 6R) 6-(3-Propylthio-1, 2, 5-thiadiazol-4-yl)-1-azabicyclo [3.2.1] Octane on a Mouse Model of Neuropathic Pain[J]. Anesthesia and Analgesia, 2017, 124(4): 1330.
Wang, YJ, Liu, MG, Wang, JH, Cao, W, Wu, C, Wang, ZY, ... & Li, XY (2020). Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity. Cell Reports, 33(6), 108369.
Wang, YJ, and ZH Huang. Microglia Interact with Neurons by Forming Somatic Junctions. Neuroscience Bulletin 36 (2020): 1085-1088.
Tian, YL*, Yang, CJ*, Cui, YX*, Su, F*, Wang, YJ*, Wang, YZ*, ... & Zhu, D. (2018). An excitatory neural assembly encodes short-term memory in the prefrontal cortex. Cell Reports, 22(7), 1734-1744. (*co-first author)
Zuo ZX*, Wang YJ*, Liu L, et al. Huperzine A alleviates mechanical allodynia but not spontaneous pain via muscarinic acetylcholine receptors in mice[J]. Neural plasticity, 2015, 2015.(*co-first author)
Cao, Liying, Yongjie Wang, and Zhihui Huang. "Reversion of Injured Adult Neurons to an Embryonic State by Grafts of Neural Progenitor Cells After Spinal Cord Injury." Neuroscience Bulletin 37.2 (2021): 271-274.
Jiang, Yuanyuan, Yongjie Wang, and Zhihui Huang. "Targeting PTB as a One-Step Procedure for In Situ Astrocyte-to-Dopamine Neuron Reprogramming in Parkinson’s Disease." Neuroscience Bulletin 37.3 (2021): 430-432.
Li, XY, Wang, N, Wang, YJ, Zuo, Z. X., Koga, K., Luo, F., & Zhuo, M. (2014). Long-term temporal imprecision of information coding in the anterior cingulate cortex of mice with peripheral inflammation or nerve injury. Journal of Neuroscience, 34(32), 10675-10687.
Shi, Jiali, Shanshan Sun, Yongjie Wang and Zhihui Huang. "Reprogramming Restores Vision in Mice by Changing DNA Methylation." Neuroscience Bulletin (2021): 1-3.
Sun, Shanshan, Jiali Shi, Yongjie Wang and Zhihui Huang "A Temporal Precision Approach for Deep Transcranial Optogenetics with Non-invasive Surgery." Neuroscience Bulletin (2021): 1-4.
Huang, Yuqian, Yongjie Wang, and Zhihui Huang. "A Specific Peptide Vaccine Against IDH1 (R132H) Glioma." Neuroscience Bulletin 38.2 (2022): 223-225.
Zhang, SX, Chen, YR, Wang, YJ, Zhang, P, Chen, G, & Zhou, YF (2020). Insights Into Translatomics in the Nervous System. Frontiers in Genetics, 11.
Yu, H, Zhang, P, Chen, YR, Wang, YJ, Lin, XY, Li, XY, & Chen, G (2019). Temporal Changes of Spinal Transcriptomic Profiles in Mice With Spinal Nerve Ligation. Frontiers in Neuroscience, 13, 1357.
Yang, J, Yuan, F, Ye, G, Wang, YJ, Wu, C, Wang, J, ... & Feng, Z. (2019). Skin/muscle incision and retraction induces evoked and spontaneous pain in mice. Pain Research and Management, 2019.
Mei, X, Yang, Y, Zhao, J, Wang, YJ, Chen, Q, Qian, X, ... & Feng, Z. (2020). Role of fragile X mental retardation protein in chronic pain. Molecular Pain, 16, 1744806920928619.