课题组长:陈大竞
课题组成员:朱芹,赵加茜,张心然,汪程成,刘玉桥,朱灵,李俊敏
课题组长简介:
陈大竞,现杭州师范大学医学部药学院教授。2006年本科毕业于浙江大学生物医学工程与仪器科学学院,2011年博士毕业于浙江大学生物传感器国家专业实验室,2012-2013年在美国University of Texas, Austin开展博士后研究,2014-2016在美国Dartmouth College担任研究助理。曾获得国家科学技术进步二等奖、教育部科学技术进步二等奖、浙江省级人才、杭州市级人才、杭州市C类领军人才等奖项。
课题组研究领域:
细胞传感与药物分析、肿瘤类器官芯片
生物医学传感与快速诊断、代谢类标志物连续检测
微纳尺度生物功能材料
课题组科研成果
科研项目:
国家自然科学基金青年项目,基于多孔膜受限空间非束缚粒子的微结构调控及其生化传感研究,61801160,主持
浙江省探索公益研究项目,基于非对称传质膜的药物代谢穿戴式传感器,LTGY23H180002,主持
浙江省自然科学基金面上项目,薄纸型多孔微流体生化快速检测传感器,LY18H180009,主持
高层次留学回国人员在杭创业创新项目资助,三维限域结构的生化修饰及癌症标志物检测应用,主持
奖励:
浙江省钱江人才计划
杭州市全球引才521计划
杭州市C类领军人才
教育部科技进步一等奖(9/15)
国家科技进步二等奖(8/10)
实验室学生获奖:
国家奖学金(2023、2022、2021)、浙江省级优秀毕业生(2023、2022、2021)、浙江省新苗人才项目(2022、2021)
浙江省互联网+大学生创新创业大赛金奖(2023)、铜奖(2022);中国生物医学工程创新赛三等奖(2022);浙江省挑战杯竞赛铜奖(2022)、
杭州师范大学精进杯学术竞赛一等奖(2022)、二等奖(2023、2021);杭州师范大学希望杯创业大赛金奖(2023、2022)、杭州师范大学互联网+大学生创新创业大赛一等奖(2023、2022)
近期代表性论文(通讯/一作):
1. Tumor cell membrane-coated continuous electrochemical sensor for GLUT1 inhibitor screening. Journal of Pharmaceutical Analysis. 2023. 13(6), 673 (一区, IF=8.8)
2. Facile fabrication of laser induced versatile graphene-metal nanoparticles electrodes for the detection of hazardous molecules. Talanta. 2023, 257, 124368 (一区, IF=6.1)
3. Measurement of sucrose in beverages using a blood glucose meter with cascade-catalysis enzyme particle. Food Chemistry. 2023, 398, 133951(一区, IF=9.231)
4. An enzyme-particle hybrid ink for one step screen-printing and long-term metabolism monitoring. Analytica Chimica Acta. 2022, 1221, 340168(二区TOP, IF=6.911)
5. A cellular nitric oxide sensor based on porous hollow fiber with flow-through configuration. Biosensors and Bioelectronics . 2021, 191, 113442(一区, IF=12.545)
6. Size controlled fabrication of enzyme encapsulated amorphous calcium phosphate nanoparticle and its intracellular biosensing application. Colloids and Surfaces B: Biointerfaces. 2021, 201, 111638. (二区TOP, IF=5.999)
7. Modular assembly of enzyme loaded nanoparticles in 3D hollow fiber electrode for electrochemical sensing. Chemical Engineering Journal, 2021. (一区, IF=16.744)
8. The micro-volume liquid focusing effect in Janus membrane and its biosensing application. Journal of Colloid and Interface Science, 2021, 592, 22-32. (一区, IF=9.965)
9. Capillary-driven blood separation and in-situ electrochemical detection based on 3D conductive gradient hollow fiber membrane. Biosensors and Bioelectronics, 2020, 171, 112722. (一区, IF=12.545)
10. In-situ monitoring of glucose metabolism in cancer cell microenvironments based on hollow fiber structure. Biosensors and Bioelectronics, 2020, 162, 112261. (一区, IF=12.545)
11. A porous hollow fiber sensor for detection of cellular hydrogen peroxide release based on cell-in-lumen configuration. Sensors and Actuators B: Chemical, 2020. 321, 128516. (一区, IF=9.221)
12. Three-dimensional microporous hollow fiber membrane microfluidic device Integrated with selective separation and capillary self-driven for point-of-care testing. Analytical Chemistry, 2020, 92 (9), 6358-6365. (一区, IF=8.008)
13. Construction of flexible enzymatic electrode based on gradient hollow fiber membrane and multi-wall carbon tubes meshes. Biosensors and Bioelectronics, 2020. 152: p. 112001. (一区, IF=12.545)
14. Top-down strategy of implantable biosensor using adaptable, porous hollow fibrous membrane. ACS sensors, 2019.4, 931-937 (一区,IF=9.618)
联系方式:
电子邮箱:djchen@hznu.edu.cn