一、导师基本情况
姓名：沈嘉炜，化学博士，教授，博士生导师
办公电话：0571-28863425
邮箱：shenjiawei@hznu.edu.cn；shen.jiawei@hotmail.com
指导专业：药学、生物学
二、研究领域
1. 生物纳米材料及药物递送材料的计算机模拟
2. 药学递送系统的构建及在抗肿瘤、皮肤病等领域的应用
3. 膜分离材料的多尺度模拟及分子设计
三、主讲课程
1. 《药物化学》
2. 《药物化学实验》
3. 《生物信息学与新药研发》
四、教育和工作经历
2000年9月--2004年6月，浙江大学，理学学士
2004年9月--2009年6月，浙江大学，理学博士
2009年9月--2013年6月，德国马普高分子研究所，博士后研究员
2013年6月--2020年6月，杭州师范大学医学院，教授
2020年7月--2021年6月，杭州师范大学医学部药学院，教授，副院长
2021年7月—至今，杭州师范大学药学院，教授，副院长
五、学术简介
沈嘉炜，教授、博士生导师，现任杭州师范大学药学院副院长，中国抗癌协会中西整合控瘤新药研究专业委员会委员，浙江省转化医学会皮肤病学分会常务委员。2004年及2009年在浙江大学化学系获得理学学士和理学博士学位，2009年9月至2013年6月在德国马克斯-普朗克高分子研究所（Max-Planck Institute for Polymer Research）进行博士后研究工作，2013年6月加入杭州师范大学。近年来研究工作集中在生物纳米材料及药物递送材料的计算机模拟、药学递送系统的构建及在抗肿瘤、皮肤病等领域的应用等。目前已主持国家自然科学基金4项，浙江省自然科学基金、浙江省钱江人才项目等纵向、横向课题10余项，浙江省一流课程负责人，入选浙江省级人才计划、杭州市特殊支持创新领军人才等。发表SCI收录论文90余篇，其中以第一作者和通讯作者Biomaterials、Journal of Controlled Release、Nano Today、Chemical Engineering Journal、Biosensors & Bioelectronics、Journal of Physical Chemistry Letter、Carbohydrate Polymers、Journal of Membrane Science、Journal of Nanobiotechnology、Bioresource Technology等权威SCI期刊发表论文68篇，总被引2600余次。
六、代表性教学科研项目
1. 壳聚糖作为难溶性抗癌药物递送材料的计算机模拟和分子设计研究、国家自然科学基金面上项目、2024.01-2027.12、主持
2. 石墨烯量子点及其衍生物跨膜传递的分子模拟研究、国家自然科学基金面上项目、2020.01-2023.12、主持
3. 仿生石墨烯纳米孔道中基因传递的多尺度模拟研究、国家自然科学基金面上项目、2017.01-2020.12、主持
4. 多肽与无机晶体相互作用的多尺度模拟方法研究、国家自然科学基金青年项目、2015.01-2017.12、主持
5.《药物化学》浙江省一流课程、2021.05-2026.04、主持
七、 代表性论著
1. Lushuang Xu, Qinyue Chen, Yangwei Qian, Jin Wang, Chenxi Wang, Rui Fan, Jia-Wei Shen*, Qiying Shen*, NIR-activatable proenzyme DSF/CuS@M for synergistic in situ chemotherapy/CDT/PTT/cuproptosis-based antitumor therapy, Chemical Engineering Journal, 2025, 510, 161733.
2. Yangwei Qian, Chenxi Wang, Ruru Xu, Jin Wang, Qinyue Chen, Zirui Zhu, Quan Hu*, Qiying Shen*, Jia-Wei Shen*, Copper-based metal–organic frameworks for antitumor application. Journal of Nanobiotechnology, 2025, 23, 135.
3. Wei Duan, Yue Gao, Ruru Xu, Sheng Huang, Xueqian Xia, Jingwen Zhao, Longhuan Zeng, Qiaolin Wei, Jia-Wei Shen*, Jianmin Wu, Yongke Zheng. Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing. Materials Today Bio, 2025, 31, 101522.
4. Xiaorong Yang#, Hong Zhang#, Zehua Wu, Qin Chen, Wei Zheng, Qiying Shen, Qiaolin Wei*, Jia-Wei Shen*, Yong Guo*. Tumor therapy utilizing dual-responsive nanoparticles: A multifaceted approach integrating calcium-overload and PTT/CDT/chemotherapy. Journal of Controlled Release, 2024, 376, 646-658.
5. Yue Li, Zirui Zhu, Shiyuan Hua, Yinghong Wan, Qin Chen, Ge Gao, Hong Zhang, Wei Duan, Wei Zheng, Yong Guo, Quan Hu, Jia-Wei Shen*, Min Zhou*, Qiaolin Wei*. Metal-based nanoparticles promote the activation of cGAS-STING pathway for enhanced cancer immunotherapy. Nano Today, 2024, 58, 102445.
6. Hong Zhang, Xiao Wang, Xiaorong Yang, Zehua Wu, Qin Chen, Qiaolin Wei, Yong Guo*, Quan Hu*, Jia-Wei Shen*. NIR-triggered and Thermoresponsive Core-shell nanoparticles for synergistic anticancer therapy. Journal of Controlled Release, 2024, 374, 194-204.
7. Di Hu, Ruru Xu, Yating Jin, Shuqing Sun, Jing Ye, Jiajia Wu, Zhiyuan Dai, Jia-Wei Shen*, Yanbin Lu*. Green and sustainable extraction of phycocyanin from Spirulina platensis by temperature-sensitive polymer-based aqueous two-phase system and mechanism study. Bioresource Technology, 2024, 407, 131142.
8. Wei Duan, Jingwen Zhao, Yue Gao, Keying Xu, Sheng Huang, Longhuan Zeng, Jia-Wei Shen*, Yongke Zheng*, Jianmin Wu*. Porous silicon-based sensing and delivery platforms for wound management applications. Journal of Controlled Release, 2024, 371, 530-554.
9. Tianyu Li, Jiachen Li, Zhe Kong, Yiran Peng, Jia-Wei Shen*, Li Zhang, Lijun Liang*. Charge govern ion-selective mechanism of YX2 desalination pore using high-throughput computations and machine learning. Desalination, 2024, 584, 117737.
10. X.Y. Liu, X.Y. Liang, J. Yu, K.Y. Xu, J.W. Shen*, Wei Duan*, J.B. Zeng*. Recent development of noble metal-based bimetallic nanoparticles for colorimetric sensing, TrAC-Trends in Analytical Chemistry, 2023, 169, 117386.
11. J.W. Shen*,#, J.C. Li#, J.H. Dai, M.D. Zhou, H. Ren, L. Zhang, Q. Hu, Z. Kong, L.J. Liang*. Molecular dynamics study on the adsorption and release of doxorubicin by chitosan-decorated graphene. Carbohydrate Polymers, 2020, 248, 116809.
12. C. Chen, L.J. Jia, J.C. Li, L. Zhang*, L.J. Liang, E.Y. Chen, Z. Kong, X.P. Wang, W. Zhang, J.W. Shen*. Understanding the effect of hydroxyl/epoxy group on water desalination through lamellar graphene oxide membranes via molecular dynamics simulation. Desalination, 2020, 491, 114560.
13. J.W. Shen*, J.C. Li, F. Liu, L. Zhang*, L.J. Liang, H.B. Wang*. A molecular dynamics study on water desalination using single-layer MoSe2 nanopore. Journal of Membrane Science, 2020, 595, 117611.
14. Z.Y. Xue, Q. Sun, L. Zhang, Z.Z. Kang, L.J. Liang, Q. Wang*, J.W. Shen*. Graphene quantum dot assisted translocation of drugs into a cell membrane, Nanoscale, 2019, 11, 4503-4514.
15. L.J. Liang*, J.W. Shen*, Z.S. Zhang, Q. Wang*. DNA sequencing by two-dimensional materials: As theoretical modeling meets experiments. Biosensors & Bioelectronics, 2017, 89, 280-292.
16. J.W. Shen*, Z. Kong, L. Zhang, L.J. Liang*. Controlled interval of aligned carbon nanotubes arrays for water desalination: A molecular dynamics simulation study. Desalination, 2016, 395, 28-32.
17. J.W. Shen, C.L. Li, N.F.A. van der Vegt, C. Peter*. Understanding the control of mineralization by polyelectrolyte additives: simulation of preferential binding to calcite surfaces. Journal of Physical Chemistry C, 2013, 117, 6904-6913.
18. J.W. Shen, C.L. Li, N.F.A. van der Vegt, C. Peter*. Transferability of coarse grained potentials: implicit solvent models for hydrated ions. Journal of Chemical Theory and Computation, 2011, 7, 1916-1927.
19. J.W. Shen, T. Wu*, Q. Wang*, H.H. Pan. Molecular simulation of protein adsorption and desorption on hydroxyapatite surfaces. Biomaterials, 2008, 29, 513-532. (Leading Opinion Paper, one of 12 figures featured in “2008 - The Year in Images” of Biomaterials)
20. J.W. Shen, T. Wu*, Q. Wang*, Y. Kang. Induced stepwise conformational change of human serum albumin on carbon nanotube surfaces. Biomaterials, 2008, 29, 3847-3855. (one of 12 figures featured in “2008 - The Year in Images” of Biomaterials)
八、成果奖励
1. 新型稀缺酶资源研发体系创建及其在医药领域应用、教育部科学技术进步一等奖、2019年1月、16/17
2. 杭州市教育局系统优秀教师、2018年8月