一、导师基本情况
姓名：沈嘉炜，化学博士，教授（硕士生导师）
办公电话：0571-28863425
邮箱：shenjiawei@hznu.edu.cn.
指导专业：药学、生理学
二、研究领域
1. 生物纳米材料及药物载体材料的计算机模拟、分子设计及实验研究
2. 生物分子与纳米材料相互作用的多尺度模拟
3. 海水淡化材料的计算机模拟与分子设计
三、主讲课程
1. 《药物化学》
2. 《药物化学实验》
3. 《分子模拟与计算机辅助药物分子设计》
4. 《生物信息学与新药研发》
四、教育和工作经历
2000年9月--2004年6月，浙江大学，理学学士
2004年9月--2009年6月，浙江大学，理学博士
2009年9月--2013年6月，德国马普高分子研究所，博士后研究员
2013年6月--2020年6月，杭州师范大学医学院，教授
2020年7月--2021年6月，杭州师范大学医学部药学院，教授，副院长
2021年7月—至今，杭州师范大学药学院，教授，副院长
五、学术简介
沈嘉炜，博士、教授，现任杭州师范大学药学院副院长。2004年及2009年在浙江大学化学系获得理学学士和理学博士学位，2009年9月至2013年6月在德国马克斯-普朗克高分子研究所（Max-Planck Institute for Polymer Research）进行博士后研究工作，2013年6月加入杭州师范大学。近年来研究工作集中在生物纳米材料及药物载体材料的计算机模拟、分子设计，新型纳米药物递送系统的设计、制备及其在抗肿瘤、抗炎治疗中的应用等。目前已主持国家自然科学基金3项，浙江省自然科学基金、高层次留学回国人员在杭创新项目等多项，入选浙江省级人才、杭州市131人才计划等。发表SCI收录论文68篇，其中以第一作者和通讯作者在Biomaterials、Biosensors & Bioelectronics、Nanoscale、Journal of Physical Chemistry Letter、Carbohydrate Polymers、Journal of Membrane Science、Desalination、Journal of Materials Chemistry B、International Journal of Pharmaceutics、International Journal of Biological Macromolecules、Journal of Chemical Theory and Computation、Journal of Physical Chemistry C、Langmuir等权威SCI期刊发表论文45篇，总被引1700余次。
六、主持教学科研项目
1. 石墨烯量子点及其衍生物跨膜传递的分子模拟研究、国家自然科学基金面上项目、65万、2020.01-2023.12、主持
2. 仿生石墨烯纳米孔道中基因传递的多尺度模拟研究、国家自然科学基金面上项目、65万、2017.01-2020.12、主持
3. 多肽与无机晶体相互作用的多尺度模拟方法研究、国家自然科学基金青年项目、25万、2015.01-2017.12、主持
4. 多肽与碳酸钙晶体表面相互作用的多尺度模拟研究、浙江省自然科学基金一般项目、8万、2014.01-2016.12、主持、（结题优秀）
5. 基因传递高分子载体材料的计算机模拟与分子设计、浙江省“钱江人才计划”D 类项目择优资助、5万、2017.01-2019.12、主持
6. 石墨烯及其衍生物纳米膜作为海水淡化材料的分子设计研究、高层次留学回国人员在杭创业创新项目、10万、2019.01-2021.12、主持
7. 《药物化学》浙江省一流课程、2021.05-2026.04、主持
七、代表性论著
1. J.H. Dai, J.L. Sun, L.S. Xu, Y.X. Lu, X.Y. Xu, Q. Hu*, L.J. Liang, T. Xie*, J.W. Shen* Dynamics of electric field-controlled methotrexate delivery through membrane nanochannels. Journal of Molecular Liquids, 2022, 350, 118525.
2. J.C. Li, H. Chen, S.X. Liu, Z.Z. Kang, L.S. Yu, L.J. Liang, J.W. Shen*, Y.C. Liu, J. Fan, Q*. Wang*. Understanding the anchoring interaction of coagulation factor Va light chain on zeolites: A molecular dynamics study. Journal of Colloid and Interface Science, 2022, 608, 435-445.
3. W.J. Zhao, L.J. Liang*, Z. Kong, J.W. Shen*. A Review on desalination by graphene-based biomimetic nanopore: From the computational modelling perspective. Journal of Molecular Liquids, 2021, 342, 117582.
4. L.J. Liang#, Z.S. Zhang#, H.B. Wang, J.W. Shen*, Z. Kong*. Direct proof of soft knock-on mechanism of ion permeation in a voltage gated sodium channel. International Journal of Biological Macromolecules, 2021, 188, 369-374. (SCI, 二区, IF = 6.953)
5. H.X. Zhou, Z.X Xie, L.J. Liang*, P.Z. Zhang, X.C. Ma, Z. Kong, J.W. Shen*, W. Hu. Theoretical investigation on the adsorption orientation of DNA on two-dimensional MoSe2. Chemical Physics, 2021, 551, 111329. (SCI, 三区, IF = 2.348)
6. Z. Kong, P.Z. Zhang, J.X. Chen, H.X. Zhou, X.C. Ma, H.B. Wang, J.W. Shen*, L.J. Liang*. Effect of shape on the entering of graphene quantum dots into a membrane: A molecular dynamics simulation. ACS Omega, 2021, 6, 10936-10943.
7. L.J. Liang, X.M. Peng, F.F. Sun, Z. Kong*, J.W. Shen*. A review on the cytotoxicity of graphene quantum dots: from experiment to simulation. Nanoscale Advances, 2021, 3, 904-917.
8. J.W. Shen*,#, J.C. Li#, J.H. Dai, M.D. Zhou, H. Ren, L. Zhang, Q. Hu, Z. Kong, L.J. Liang*. Molecular dynamics study on the adsorption and release of doxorubicin by chitosan-decorated graphene. Carbohydrate Polymers, 2020, 248, 116809.
9. H. Ren#, X. Shen#, J.H. Dai, G.T. Peng, L.J. Liang, J.W. Shen*, L. Zhang*. On the mechanism of graphene quantum dot encapsulation by chitosan: A molecular dynamics study. Journal of Molecular Liquids, 2020, 320, 113453.
10. C. Chen, L.J. Jia, J.C. Li, L. Zhang*, L.J. Liang, E.Y. Chen, Z. Kong, X.P. Wang, W. Zhang, J.W. Shen*. Understanding the effect of hydroxyl/epoxy group on water desalination through lamellar graphene oxide membranes via molecular dynamics simulation. Desalination, 2020, 491, 114560.
11. J.C. Li, S.B. Ying, H. Ren, J.H. Dai, L. Zhang, L.J. Liang, Q. Wang, Q.Y. Shen*, J.W. Shen*. Molecular dynamics study on the encapsulation and release of anti-cancer drug doxorubicin by chitosan. International Journal of Pharmaceutics, 2020, 580, 119241.
12. J. Zhang, C. Chen, J.N. Pan, L. Zhang*, L.J. Liang, Z. Kong, X.P. Wang, W. Zhang, J.W. Shen*. Atomistic insights into the separation mechanism of multilayer graphene membranes for water desalination. Physical Chemistry Chemical Physics, 2020, 22, 7224-7233.
13. J.W. Shen*, J.C. Li, F. Liu, L. Zhang*, L.J. Liang, H.B. Wang*. A molecular dynamics study on water desalination using single-layer MoSe2 nanopore. Journal of Membrane Science, 2020, 595, 117611.
14. L.J. Liang, Y.J. Zhang, Z. Kong, F. Liu, J.W. Shen*, Z.W. He, H.B. Wang*. DNA fragment translocation through the lipid membrane assisted by carbon nanotube. International Journal of Pharmaceutics, 2020, 574, 118921.
15. 周梦迪，沈嘉炜*，梁立军，李嘉辰，金乐红*，王琦，石墨烯生物毒性的计算机模拟研究进展，化工学报，2020, 71(1), 148-165.
16. L. Zhang*, L.J. Jia, J. Zhang, J.C. Li, L.J. Liang, Z. Kong, J.W. Shen*, X.P. Wang, W. Zhang, H.B. Wang. Understanding the effect of chemical modification on water desalination in boron nitride nanotubes via molecular dynamics simulation. Desalination, 2019, 464, 84-93.
17. Z.Y. Xue, Q. Sun, L. Zhang, Z.Z. Kang, L.J. Liang, Q. Wang*, J.W. Shen*. Graphene quantum dot assisted translocation of drugs into a cell membrane, Nanoscale, 2019, 11, 4503-4514.
18. M.D. Zhou, Q.Y. Shen, J.W. Shen*, L.H. Jin, L. Zhang, Q. Sun, Q. Hu, L.J. Liang*. Understanding the size effect of graphene quantum dots on protein adsorption, Colloids and Surfaces B: Biointerfaces, 2019, 174, 575-581.
19. L.J. Liang*, F. Liu, Z. Kong, J.W. Shen*, H.B. Wang, H.D. Wang, L.H. Li. Theoretical studies on key factors in DNA sequencing using atomically thin molybdenum disulfide nanopores. Physical Chemistry Chemical Physics, 2018, 20, 28886-28893.
20. L. Zhang, G.T. Peng, J.C. Li, L.J. Liang, Z. Kong, H.B. Wang, L.J. Jia, X.P. Wang, W. Zhang, J.W. Shen*. Molecular dynamics study on the configuration and arrangement of doxorubicin in carbon nanotubes. Journal of Molecular Liquids, 2018, 262, 295-301.
21. L. Zhang, J.C. Li, G.T. Peng, L.J. Liang, Z. Kong, J.W. Shen*, L.J. Jia, X.P. Wang, W. Zhang. Charge-tunable water transport through boron nitride nanotubes. Journal of Molecular Liquids, 2018, 258, 95-105.
22. L. J. Liang#, J. C. Li#, L. Zhang, Z. S. Zhang, J.W. Shen*, L. H. Li*, J. Y. Wu. Computer simulation of water desalination through boron nitride nanotubes. Physical Chemistry Chemical Physics, 2017, 19, 30031-30038.
23. Z.Y. Xue, Q.Y. Shen, L.J. Liang, J.W. Shen*, Q. Wang*. Adsorption behavior and mechanism of SCA-1 on calcite surface: A molecular dynamics study. Langmuir, 2017, 33, 11321-11331.
24. J.W. Shen*, J.C. Li, Z. N. Zhao, L. Zhang*, G. T. Peng, L.J. Liang*. Molecular dynamics study on the mechanism of polynucleotide encapsulation by chitosan. Scientific Reports, 2017, 7, 5050.
25. Z. Kong, H.B. Wang, L.J. Liang*, Z.S. Zhang, S.B. Ying, Q. Hu, J.W. Shen*. Investigation of the morphological transition of a phospholipid bilayer membrane in an external electric field via molecular dynamics simulation. Journal of Molecular Modeling, 2017, 23, 113.
26. L.J. Liang, W. Hu*, Z.Y. Xue, J.W. Shen*. Theoretical study on the interaction of nucleotides on two-dimensional atomically thin graphene and molybdenum disulfide. FlatChem, 2017, 2, 8-14.
27. L.J. Liang*, J.W. Shen*, Q. Wang. Molecular dynamics study on DNA nanotubes as drug delivery vehicle for anticancer drugs. Colloids and Surfaces B: Biointerfaces, 2017, 153, 168-173.
28. L.J. Liang*, J.W. Shen*, Z.S. Zhang, Q. Wang*. DNA sequencing by two-dimensional materials: As theoretical modeling meets experiments. Biosensors & Bioelectronics, 2017, 89, 280-292.
29. L.J. Liang#, W. Hu#, Z.S. Zhang*, J.W. Shen*, Theoretic study on dispersion mechanism of boron nitride nanotubes by polynucleotides. Scientific Reports, 2016, 6, 39747.
30. L.J. Liang*, Z.Z. Kang, J.W. Shen*. Translocation mechanism of C60 and C60 derivations across a cell membrane. Journal of Nanoparticle Research, 2016, 18, 333.
31. L.J. Liang*, L.W. Wang, J.W. Shen*. The self-assembly mechanism of tetra-peptides from the motif of beta-amyloid peptides: a combined coarse-grained and all-atom molecular dynamics simulation. RSC Advances, 2016, 6, 100072-100078.
32. L.J. Liang*, Z. Kong, Z.Z. Kang, H.B. Wang, L. Zhang, J.W. Shen*. Theoretical evaluation on potential cytotoxicity of graphene quantum dots. ACS Biomaterials Science & Engineering, 2016, 2, 1983-1991.
33. J.W. Shen*, Z. Kong, L. Zhang, L.J. Liang*. Controlled interval of aligned carbon nanotubes arrays for water desalination: A molecular dynamics simulation study. Desalination, 2016, 395, 28-32.
34. L.J. Liang, Z.S. Zhang, Z. Kong, Y. Liu, J.W. Shen*, D.B. Li, Q. Wang*. Charge-tunable insertion process of carbon nanotubes into DNA nanotubes. Journal of Molecular Graphics and Modelling, 2016, 66, 20-25.
35. L.J. Liang, E.Y. Chen, J.W. Shen*, Q. Wang*. Molecular modelling of translocation of biomolecules in carbon nanotubes: method, mechanism and application, Molecular Simulation, 2016, 42, 827-835.
36. Z. Kong, W. Zheng, Q. Wang, H. B. Wang, F. N. Xi, L. J. Liang*, J.W. Shen*. Charge-tunable absorption behavior of DNA on graphene, Journal of Materials Chemistry B, 2015, 3, 4814-4820.
37. J.W. Shen, T. Tang, X.H. Wei, W. Zheng, T.Y. Sun, Z. S. Zhang, L. J. Liang*, Q. Wang*. On the loading mechanism of ssDNA into carbon nanotubes. RSC Advances, 2015, 5, 56896-56903.
38. Z.S. Zhang#, J.W. Shen#, H.B. Wang, Q. Wang*, J.Q. Zhang, L.J. Liang*, H. Agren, Y.Q. Tu. Effects of graphene nanopore geometry on DNA sequencing. Journal of Physical Chemistry Letters, 2014, 5, 1602-1607.
39. P. Shan#, J.W. Shen#, D.H. Xu, L.Y. Shi, J. Gao, Y.W. Lan, Q. Wang*, X.H. Wei*. Molecular dynamics study on the interaction between doxorubicin and hydrophobically modified chitosan oligosaccharide. RSC Advances, 2014, 4, 23730-23739.
40. J.W. Shen, C.L. Li, N.F.A. van der Vegt, C. Peter*. Understanding the control of mineralization by polyelectrolyte additives: simulation of preferential binding to calcite surfaces. Journal of Physical Chemistry C, 2013, 117, 6904-6913.
41. J.W. Shen, C.L. Li, N.F.A. van der Vegt, C. Peter*. Transferability of coarse grained potentials: implicit solvent models for hydrated ions. Journal of Chemical Theory and Computation, 2011, 7, 1916-1927.
42. J.W. Shen, T. Wu*, Q. Wang*, Y. Kang, X. Chen. Adsorption of insulin peptide on charged single-walled carbon nanotubes: significant role of ordered waters. ChemPhysChem, 2009, 10, 1260-1269.
43. J.W. Shen, T. Wu*, Q. Wang*, H.H. Pan. Molecular simulation of protein adsorption and desorption on hydroxyapatite surfaces. Biomaterials, 2008, 29, 513-532. (Leading Opinion Paper, one of 12 figures featured in “2008 - The Year in Images” of Biomaterials)
44. J.W. Shen, T. Wu*, Q. Wang*, Y. Kang. Induced stepwise conformational change of human serum albumin on carbon nanotube surfaces.
45. J.W. Shen, T. Wu, Y.G. Wang, Q. Wang*. Quantum mechanics study on the selectivity of alkali metal cations by a novel fluorescent chemosensor. Molecular Simulation, 2006, 32, 1123-1129.
八、成果奖励（省部级以上）
1. 新型稀缺酶资源研发体系创建及其在医药领域应用、教育部科学技术进步一等奖、2019年1月、16/17
2. 杭州市教育局系统优秀教师、2018年8月