导师介绍
潘宗富(浙江省人民医院)
来源:药学院|日期:2023-05-22|点击:2
 

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潘宗富

一、导师基本情况

姓名:潘宗富,药理学博士,副主任药师(硕士生导师)

邮箱:panzongfu@163.com

指导专业:药学

导师单位:浙江省人民医院

二、研究领域

1.肿瘤免疫逃逸新机制及新靶点、肿瘤药理

2.肿瘤演进转录调控蛋白质复合物解析

3.甲状腺癌多组学队列研究

4.斑马鱼-PDX模型构建及应用

三、主讲课程

新药与研发(研究生课程)

四、教育和工作经历

20119-20166月,浙江大学,药理学博士

20079-20116月,厦门大学,药学学士

2016-72018-12, 浙江省肿瘤医院, 药剂科, 药师

2018-122019-12, 浙江省肿瘤医院, 药剂科, 主管药师

2020-12020-12, 杭州医学院,附属人民医院(浙江省人民医院), 药学部, 主管药师

2020-12至现在, 杭州医学院,附属人民医院(浙江省人民医院), 药学部, 副主任药师

、学术简介(限200字内)

浙江省卫生高层次人才医坛新秀培养对象,临床药学中心后备学科带头人,省内分泌腺体疾病诊治研究重点实验室骨干成员,聚焦肿瘤免疫逃逸新机制、新靶点,以及治疗性抗体的开发。主持国家自然科学基金2项,浙江省自然科学基金等8项,以一作或通讯在Molecular CancerCancer LettersCell Death & Disease等期刊发表论文20篇。

浙江省预防医学会甲状腺疾病预防与控制专业委员会委员

浙江省药学会临床药学专业委员会委员

浙江省药学会药物毒理学专业委员会青年委员

、主持教学科研项目

·HN1-CCL2-VSIG4信号轴驱动未分化甲状腺癌免疫逃逸的作用及机制,国家自然科学基金面上项目,20221-202512

·微管结合蛋白HN1在未分化甲状腺癌失分化中的作用及机制研究,国家自然科学基金青年项目,20191-202112

·HN1介导DNA结合蛋白CTCF转录沉默致甲状腺癌失分化重编程的作用及机制研究,浙江省基础公益研究计划项目,20221-202412

·未分化甲状腺癌诱导肿瘤相关巨噬细胞表达新型免疫调节分子VSIG4机制研究,浙江省基础公益研究计划项目,20181-202012

·春花益肺颗粒制剂开发及其抗肺纤维化作用研究,浙江省中医药科技计划项目(重点研究项目),20221-202412

·微管结合蛋白HN1维持未分化甲状腺癌肿瘤干性的作用及机制,浙江省医药卫生科技计划项目(A类项目),20221-202412

·转录因子 OASIS 过度激活介导未分化甲状腺癌恶性表型的作用及机制,浙江省医药卫生科技计划项目(A类项目),20211-202312

·中药莱菔子提取物调节肿瘤基质重塑促进化疗增敏的效应及机制研究,浙江省中医药科技计划项目(A类项目),20209-20229

·基于JP3/4-cAMP-LKB1通路研究人参皂苷Rg1促神经极化作用机制。浙江省医药卫生科技计划(A类项目),20171-201912

·人参皂苷Rg1预处理移植神经干细胞促缺血性脑损伤大鼠神经功能修复研究,浙江省药学会医院药学科研专项,20171-201912

七、代表性论著

1. Yingying Gong#, Lisha Bao#, Tong Xu, Xiaofen Yi, Jinming Chen, Shanshan Wang, Zongfu Pan*, Ping Huang*, Minghua Ge*. The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy. Mol Cancer, 2023, 22(1):68. (IF=41.44,一区,top)

2. Cao Yu#, Lu Xixuan#, Fu Liping#, Shi Tao, Zhang Chong, Zeng Linghui, Zhang Jiankang, Shao Jiaan, Xi Jianjun, Pan Zongfu*, Liu Shourong*, Zhu Huajian*. Exploration of novel dihydroquinoxalinone derivatives as EGFRL858R/T790M tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer. Bioorg Chem, 2023, 135: 106494. (IF=5.307, 一区,top)

3. Pan Zongfu#; Xu Tong#; Bao Lisha#; Hu Xiaoping; Jin Tiefeng; Chen Jinming; Chen Jianqiang; Qian Yangyang; Lu Xixuan; Li Lu; Zheng Guowan; Zou Xiaozhou; Song Feifeng; Zheng Chuangming; Jiang Liehao; Wang Jiafeng; Tan Zhuo*; Huang Ping*; Ge Minghua*. CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment, Mol Cancer, 2022, 21(1): 190-208. (IF=41.44,一区,top)

4. Pan Zongfu; Bao Lisha; Lu Xixuan; Hu Xiaoping; Li Lu; Chen Jinming; Jin Tiefeng; Zhang Yiwen; Tan Zhuo; Huang Ping*; Ge Minghua*. IL2RA+VSIG4+ tumor-associated macrophage is a key subpopulation of the immunosuppressive microenvironment in anaplastic thyroid cancer, BBA-Mol Basis Dis, 2022, 1869(1): 166591-166602. (IF=6.633,二区,top)

5. Li Lu, Li Zhitao, Cui Nannan, Huang Mingzhu, Hu Xiaoping, Hong Dongsheng, Pan Zongfu*, Lu Xiaoyang*. Mitofusin2 Promotes β Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation. Stem Cells Int. 2022 Mar 27; 2022:1172795. (IF=5.131)

6. Pan Zongfu#, Fang Qilu#, Li Lu, Zhang Yiwen, Xu Tong, Liu Yujia, Zheng Xiaochun, Tan Zhuo, Huang Ping*, Ge Minghua*. HN1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by interacting with STMN1. Cancer Lett. 2021; 501:31-42. (IF=9.756,一区,top)

7. Bao Lisha, Xu Tong, Lu Xixuan, Huang Ping, Pan Zongfu*, Ge Minghua*. Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment. Front Oncol. 2021;11:773028.IF=5.7382

8. Pan Zongfu, He Ying*, Zhu Wenjuan, et al. A Dynamic Transcription Factor Signature Along the Colorectal Adenoma-Carcinoma Sequence in Patients With Co-Occurrent Adenoma and Carcinoma. Front Oncol. 2021;11:597447.IF=5.7382

9. Pan Zongfu, Li Lu, Qian Yangyang, et al. The differences of regulatory networks between papillary and anaplastic thyroid carcinoma: an integrative transcriptomics study. Cancer Biol Ther. 2020;21(9):853-862.IF=4.875

10. Pan Zongfu#, Li Lu#, Fang Qilu, et al. Integrated Bioinformatics Analysis of Master Regulators in Anaplastic Thyroid Carcinoma. Biomed Res Int. 2019; 2019:9734576-973458.IF=3.2457

11. Song Feifeng, Xuan Zixue, Yang Xiuli, Ye Xiaolan, Pan ZongFu*, Fang Qingxia*. Identification of key microRNAs and hub genes in non-small-cell lung cancer using integrative bioinformatics and functional analyses. J Cell Biochem. 2020; 121(3):2690-2703.IF=4.4807

12. Pan Zongfu#, Li Lu#, Fang Qilu, et al. Analysis of dynamic molecular networks for pancreatic ductal adenocarcinoma progression. Cancer Cell Int. 2018, 18:214-231.IF=6.4349

13. Li Lu#*, Pan Zongfu#, Xi Yang. Identification of dynamic molecular networks in peripheral blood mononuclear cells in type 1 diabetes mellitus. Diabetes Metab Syndr Obes,2019;2019(12):969-982.IF=3.2490

14. Li Lu#*, Pan Zongfu#, Yang Si, et al. Identification of key gene pathways and coexpression networks of islets in human type 2 diabetes. Diabetes Metab Syndr Obes. 2018, 11:553-563.IF=3.2490

15. Li Lu#, Pan Zongfu#, Huang Xin, et al, Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion, Cell Death Dis, 2016, 7(6): e2275.IF=9.6963

16. 潘宗富,胡晓平,张轶雯,李莉,黄萍.缺血性脑损伤大鼠外周血动态共表达网络分析. 浙江大学学报(医学版),2019, 48(6):587-593.

17.潘宗富; 方琦璐; 张轶雯; 钱杨洋; 黄萍.甲状腺未分化癌治疗研究进展:免疫疗法与分子靶向治疗. 中国药师, 2019(3):518-522.

18. 潘宗富,方琦璐,张轶雯,李莉,黄萍.基于生物信息学的未分化甲状腺癌关键发病机制及其潜在干预靶点研究. 浙江大学学报(医学版), 2018,47(2):187-193.

19.潘宗富; 张轶雯; 黄萍.外泌体在头颈部鳞癌中的研究进展. 肿瘤学杂志, 2018.

20. 潘宗富; 方琦璐; 张轶雯; 钱杨洋; 黄萍.基于生物信息学的未分化甲状腺癌恶性机制研究. 中国现代应用药学, 2018, 35(11):14-20.