姓名: 吴颖，博士，副研究员（硕士生导师）
办公电话：13918021654
邮箱：wuyingparrot@163.com
指导专业：生物化学与分子生物学、细胞生物学
课题组网站：
【研究领域】
1．肝脏组织生理/病理微环境形成和维持机制
2．内质网应激与免疫炎性、代谢性疾病的分子基础
3．免疫与代谢的细胞分子机制
【主讲课程】
无
【教育和工作经历】
1. 教育经历：
2007.9-2011.7 浙江大学，生物医学工程，学士
2011.9-2013.7 中国科学院大学，生物化学与分子生物学，硕士
2013.9-2017.7 中国科学院大学，生物化学与分子生物学，博士
2. 工作经历：
2017.4-2018.8 上海和誉生物医药科技有限公司生物部，Senior Scientist
2018.9-至今 浙江省立同德医院肿瘤研究所，副研究员
【学术简介（限200字）】
浙江省卫生高层次创新人才和浙江省科协“育才工程”培养对象，浙江省免疫学会免疫技术专委会青委，获“之江优秀青年学者奖”。作为项目负责人主持国家自然科学基金项目3项，作为主要成员参与国家科技部973计划、中欧国际合作项目、国家自然科学基金项目、浙江省自然科学基金杰青项目和浙江省重点研发计划项目等科研项目多项。在Nat Immunol、J Exp Med、Hepatology等杂志上发表SCI论文14篇，其中第一/通讯作者8篇。
【主持教学科研项目】省部级以上
1. 内质网应激IRE1a蛋白通过肝-脑轴调控化疗副作用发生的作用和机制研究，国家自然科学基金面上项目，50万元，2024.01-2027.12
2. 肝癌细胞内质网应激感应分子IRE1a调控微环境巨噬细胞表型转化的作用和机制研究，国家自然科学基金面上项目，55万元，2020.01-2023.12
3. GDF15在内质网应激IRE1a-XBP1通路促进肝癌发生发展中的作用机制研究，国家自然科学基金青年科学基金项目，25万元，2020.01-2022.12
4. 浙江省卫生高层次创新人才，80万元，2021.01-2025.12
【代表性论著】
1. Tang Yuexiao, Yao Tao, Tian Xin, Xia Xintong, Huang Xingxiao, Qin Zhewen, Shen Zhong, Zhao Lin, Zhao Yaping, Diao Bowen, Ping Yan, Zheng Xiaoxiao, Xu Yonghao, Chen Hui, Qian Tao, Ma Tao, Zhou Ben, Xu Suowen, Zhou Qimin, Liu Yong, Shao Mengle, Chen Wei, Shan Bo, Wu Ying, Hepatic IRE1a-XBP1 Signaling Promotes GDF15-mediated Anorexia and Body Weight Loss in Chemotherapy. J. Exp. Med, 2024, 10.1084/jem.20231395
2. Yao Tao, Wei Danni, Tian Xin, Zhao Lin, Wan Qiangyou, Zhang Xiaoli, Cai Juan, Li Siqi, Diao Bowen, Feng Suihan, Shan Bo, Shao Mengle, Wu Ying, PDGFRb+ cell HIF2a is Dispensable for White Adipose Tissue Metabolic Remodeling and Hepatic Lipid Accumulation in Obese Mice. Lipids in Health and Disease, 2024, 23:81
3. Ge Yunlin, Li Siqi, Yao Tao, Tang Yuexiao, Wan Qiangyou, Zhang Xiaoli, Zhao Jing, Zhang Mingliang, Shao Mengle, Wang Lijun, Wu Ying. Promotion of healthy adipose tissue remodeling ameliorates muscle inflammation in a mouse model of sarcopenic obesity. Front Nutr, 2023, 10: 1065617.
4. Wu Ying, Shan Bo, Dai Jianli, Xia Zhixiong, Cai Jie, Chen Tianwei, Lv Songya, Feng Yuxiong, Zheng Ling, Wang Yan, Liu Jianfeng, Fang Jing, Xie Dong, Rui Liangyou, Liu Jianmiao, Liu Yong, Dual role forinositol-requiring enzyme 1 alpha in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice. Hepatology, 2018.8, 68(2): 533~546.
5. Shan Bo, Wang Xiaoxia, Wu Ying(共一作者), Xu Chi, Xia Zhixiong, Dai Jianli, Shao Mengle, Zhao Feng, He Shengqi, Yang Liu, Zhang Mingliang, Nan Fajun, Li Jia, Liu Jianmiao, Liu Jianfeng, Jia Weiping, Qiu Yifu, Song Baoliang, Han JingDong J, Rui Liangyou, Duan ShengZhong, Liu Yong, The metabolic ER stress sensor IRE1 alpha suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nature Immunology, 2017.05, 18(5): 519~529.
6. Wu Ying, Tang Yuexiao, Xie Shangzhi, Zheng Xiaoxiao, Zhang Shufen, Mao Jiayan, Wang Baoming, Hou Yuerou, Hu Liqiang, Chai Kequn, Wei Chen, Chimeric peptide supramolecular nanoparticles for plectin-1 targeted miRNA-9 delivery in pancreatic cancer. Theranostics, 2020; 10(3):1151-1165.
7. Wang Hongwei, Zheng Xiaoxiao, Jin Jing, Zheng Li, Guan Ting, Huo Yangfan, Xie Shufen, Wu Ying(共同通讯), Chen Wei. LncRNA MALAT1 silencing protects against cerebral ischemia- reperfusion injury through miR-145 to regulate AQP4. Journal of Biomedical Science, 2020, 27(1),40.
8. Du Feiya, Yu Ling, Wu Ying(共一作者), Wang huqian, Yao Jia, Zheng Xiaoxiao, Xie Shangzhi, Zhang Shufeng, Yu Liu, Lu Xuemei, Chen Wei. miR-137 Alleviates Doxorubicin Resistance in Breast Cancer Through Inhibition of Epithelial-Mesenchymal Transition by Targeting DUSP4. Cell Death and Disease, 2019, 10(12):922.
9. Liu Yang, Shao Mengle, Wu Ying, Yan Cheng, Jiang Shan, Liu Jingnan, Dai Jianli, Yang Liu, Li Jia, Jia Weiping, Rui Liangyou, Liu Yong, Role for the endoplasmic reticulum stress sensor IRE1 alpha in liver regenerative responses. Journal of Hepatology, 2015.03, 62(3): 590~598.
10. Shao Mengle, Shan Bo, Liu Yang, Deng Yiping, Yan Cheng, Wu Ying, Mao Ting, Qiu Yifu, Zhou Yubo, Jiang Shan, Jia Weiping, Li Jingya, Li Jia, Rui Liangyou, Yang Liu, Liu Yong, Hepatic IRE1 alpha regulates fasting-induced metabolic adaptive programs through the XBP1s-PPAR alpha axis signaling. Nature Communications, 2014.03, 5(1): 0~3528.