一、基本情况
姓名：顾文星，理学博士，副研究员
邮箱：sdwenxing@163.com
指导专业：药学
课题组网站：谢恬教授课题组骨干成员
二、研究领域
1. 智能生物医用药用辅料
2. 分子配伍纳米药物与肿瘤化疗
3. 器官选择性靶向纳米递送系统
4. RNA靶向递送与肿瘤免疫治疗
三、主讲课程
《生物药剂学与药动学》本科生
《药物新剂型与新技术》研究生
四、教育和工作经历
2024年02月—至今 杭州师范大学药学院，副研究员
2022年03月—2023年03月 新加坡国立大学，访问研究员
2021年09月—2023年11月 北京大学深圳医院，博士后
2016年09月—2021年07月 荷兰特文特大学，高分子化学与物理，博士
2013年09月—2016年06月 天津理工大学，药物化学，硕士
2009年06月—2013年09月 天津理工大学，制药工程，学士
五、主持教学科研项目（省部级以上）
1. 国家自然科学基金青年基金，2025.01-2027.12
2. 浙江省医药卫生科技计划项目，2025.01-2027.12
3. 广东省深圳市基础研究面上项目，2022.01-2025.10
六、代表性论著（一作、共一或通讯）
1.Wenxing Gu, Qingchang Tian, Tian Xie, Xiaoyuan Chen, Genetically reprogrammed exosomes for cancer immunotherapy, Molecular Therapy, 2025.
2.Wenxing Gu, Shenhua Li, Yajie Yang, Shumin Wang, Kai Li, Yongsheng Zhao, Jing Mu, and Xiaoyuan Chen, In vivo Optical Imaging of Reactive Oxygen Species (ROS)-Related Non-Cancerous Disease, Trends Anal. Chem., 2023, 169, 117360.
3.Wenxing Gu, Jingnan An, Yaxi Li, Yajie Yang, Shumin Wang, Hui Shan, Shenhua Li, Hui Li, Guoyong Liu, Kai Li, Yuxin Yin, Jing Mu, Xiaoyuan Chen, Tuning the organ tropism of polymersome for spleen-selective nanovaccine delivery to boost cancer immunotherapy, Adv. Mater., 2023, 2301686.
4.Dandan Wang, Wenxing Gu, Weiliang Chen, Jin Zhou, Le Yu, Byung Kook Kim, Xuenong Zhang, Jong Seung Kim, Advanced nanovaccines based on engineering nanomaterials for accurately enhanced cancer immunotherapy, Coord. Chem. Rev., 2022, 472, 214788.
5.Wenxing Gu, Ruobing Qu, Fenghua Meng, Jeroen J.L.M. Cornelissen, and Zhiyuan Zhong, Polymeric nanomedicines targeting hematological malignancies, J. Control. Release, 2021, 337, 571-588.
6.Wenxing Gu, T. Liu, D. Fan, Y. Xia, F. Meng, Y. Xu, Jeroen J. L. M. Cornelissen, Z. Liu and Z. Zhong, A6 peptide-tagged, ultra-small and reduction-sensitive polymersomal vincristine sulfate as a smart and specific treatment for CD44+ acute myeloid leukemia, J. Control. Release, 2021, 329, 706-716.
7.Wenxing Gu, Fenghua Meng, Rainer Haag and Zhiyuan Zhong, Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation, J. Control. Release, 2021, 329, 676-695. (Highly cited paper)
8.Wenxing Gu, J. An, H. Meng, N. Yu, Y. Zhong, F. Meng, Y. Xu, Jeroen J.L.M. Cornelissen, and Z. Zhong, CD44-Specific A6 Short Peptide Boosts Targetability and Anticancer Efficacy of Polymersomal Epirubicin to Orthotopic Human Multiple Myeloma, Adv. Mater., 2019, 1904742.
9.L. Ding#, Wenxing Gu#, Y. Zhang, S. Yue, H. Sun, Jeroen J. L. M. Cornelissen, and Z. Zhong, HER2-Specific Reduction-Sensitive Immunopolymersomes with High Loading of Epirubicin for Targeted Treatment of Ovarian Tumor, Biomacromolecules, 2019, 20, 10, 3855.
10.Wenxing Gu, Q. Li, H. Lu, L. Fang, Q. Chen, Y.-W. Yang and H. Gao, Construction of stable polymeric vesicles based on azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery, Chem. Commun., 2015, 51, 4715.
11.Wenxing Gu, M. Zhu, N. Song, X. Du, Y.-W. Yang and H. Gao, Reverse micelles based on biocompatible β-cyclodextrin conjugated polyethylene glycol block polylactide for protein delivery, J. Mater. Chem. B, 2015, 3, 316.
12.Wenxing Gu, Y.-W. Yang, J. Wen, H. Lu and H. Gao, Construction of reverse vesicles from pseudo-graft poly(glycerol methacrylate)s via cyclodextrin–cholesterol interactions, Polym. Chem., 2014, 5, 6344.
13.Q. Li#, Wenxing Gu#, H. Gao and Y.-W. Yang, Self-assembly and applications of poly(glycidyl methacrylate)s and their derivatives, Chem. Commun., 2014, 50, 13201.
14.Wenxing Gu, Y. Ma, C. Zhu, B. Chen, J. Ma and H. Gao, Synthesis of cross-linked carboxyl poly(glycerol methacrylate) and its application for the controlled release of doxorubicin, Eur. J. Pharm. Sci., 2012, 47, 556.