姓名:段伟
邮箱:duanweichem@163.com; duanwei@hznu.edu.cn
指导专业:药学
课题组网站:https://pharmacy.hznu.edu.cn/c/2020-12-30/2497206.shtml
【研究领域】
生物活性材料、药物递送工程、新型中药制剂、纳米护肤医学
【主讲课程】
《药用高分子材料学》《药品与健康》等课程负责人
【教育和工作经历】
2014.9 - 2018.6, 中国石油大学(华东)化学系,理学学士
2018.9 - 2023.6, 浙江大学化学系,理学博士
2023.8 - 今 杭州师范大学药学院,讲师
【学术简介】
段伟,男,杭州师范大学药学院讲师,硕士生导师,浙江大学化学博士,杭州市高层次人才。主要研究方向为纳米医药与生物材料,尤其关注皮肤相关疾病(如慢性难愈创面、微生物感染、浅表肿瘤、炎症、衰老、附属器再生等)新型治疗方法的开发。目前在药用功能材料的构建、智能递药系统的设计、生物传感与诊疗技术的开发等领域取得一系列创新性的研究成果,并积极推动其在组织重塑与医美领域的临床应用。近年来以第一/通讯作者身份在Adv. Sci., Biomaterials, J. Control. Release, Environ, Sci. Technol., Anal. Chem., Acta Biomater., J. Nanobiotechnol., Trends in Anal. Chem., Biosens. Bioelectron., J. Hazard. Mater., Mater. Today Bio, MedComm等国际主流期刊上发表论文数十篇,其中影响因子(IF)大于10的中科院一区论文十余篇,累积引用超千次。同时主持多项国家级和省部级课题。以主要完成人授权国家发明专利多项,参编Elsevier英文专著1章。目前担任硅及先进半导体材料全国重点实验室客座学者,Interdiscip. Med.(一区TOP期刊, IF = 13.6)、Nano TransMed等期刊的青年编委以及Nat. Commun.等顶级期刊的审稿人。在育人方面,指导本科生第一作者发表SCI论文;指导研究生获各类奖学金及省优秀毕业研究生等荣誉称号。此外,指导学生主持国家级大学生创新创业训练项目、浙江省大学生科技创新项目(新苗计划)、星光计划一等奖、研究生科研创新推进项目重点项目、本科生创新能力提升工程、本科生科研课题等。获浙江省化学会创新奖、校优秀实习带教教师等荣誉称号。
【教学科研项目】
1. 国家自然科学基金青年项目,限域级联纳米酶的多孔硅基复合诊疗体系用于糖尿病足溃疡创面的一体化护理,2025.01-2027.12,主持
2. 浙江省自然科学基金探索项目,具有活性氧监控与调控功能的诊疗型非金属纳米酶的构建及其慢性创面联合护理研究,2025.01-2026.12,主持
3. 浙江省中医药科技计划面上项目,榄香烯智能递药水凝胶调控巨噬细胞极化促进糖尿病口腔溃疡修复的作用与机制研究,2026.01-2028.12,主持
4. 浙江省医药卫生科技计划西医项目,基于可降解多孔硅载体的智能纳米载药喷雾用于感染烧伤创面联合治疗研究,2025.01-2027.12,主持
5. 复旦大学国家重点实验室课题,新型智能水凝胶微针贴片的生物医学应用,2025.01-2025.11,主持
6. 浙江大学国家重点实验室课题,硅基材料的仿生功能构筑及其在慢性创面修复应用,2025.01-2027.12,主持
7. 浙江省生物医药接触材料重点实验室课题,构建双重响应的新型水凝胶中药制剂用于糖尿病口腔溃疡快速高质量修复研究,2026.01-2027.12,主持
8. 杭州市自然科学基金重点项目,功能响应型二维硅基药物递送材料制备及其在糖尿病创面修复中的作用与机制研究,2026.01-2028.12,主要参与
9. 杭州师范大学科研启动项目,新型药物递送体系的设计开发及其生物医学应用,2023.09-2027.09,主持
10. 杭州师范大学登峰工程有组织科研培育项目,基于多孔硅限域催化效应的智能诊疗材料用于糖尿病创面精准护理,2024.01-2024.12,主持
11. 横向课题,落新妇苷纳米结构脂质载体的制备及其用于银屑病治疗的细胞学研究,2023.11-2025.03,主持
12. 杭州师范大学教学改革项目,基于交叉学科复合式教学的公共选修课程改革研究与实践,2024.06-2026.06,主持
【代表性论著】
1. Gao, Y.; Xu, J.; Lai, Y.; Fan, Y.; Zhou, Y.; Tu, Y.; Liu, X.; Xia, X.; Wei, G.-N.*; Shen, J.-W.*; Duan, W.*; 2D nanomaterial-triggered ferroptosis in cancer therapy. Journal of Nanobiotechnology, 2026, 24(1), 81(中科院一区TOP期刊,IF=12.6)
2. Lü, J.; Wang. W.; Zhang, Y.; Xia, X.; Fan, Y.; Zhou, Y.; Tu, Y.; Shen, J.-W.*; Duan, W.*, Recent advances on nanozyme-driven technology for detecting pharmaceutical and toxic molecules. Analytical and Bioanalytical Chemistry, 2026, ASAP(中科院二区期刊,IF=3.8,本科生一作)
3. Xu, J.; Zheng, H.; Gao, Y.; Lai, Y.; Peng, M.; Hu, Y.; Yuan, T.; Liu, X.; Zhou, Y.; Duan, W.*; Shen, J.-W.*; Zheng, Y.*, The application of metal-organic frameworks as drug delivery systems: From the perspective of molecular dynamics simulations. MedComm, 2026, 7:e70692(中科院一区TOP期刊,IF=10.7)
4. Duan, W.*, Xu, K.; Gao, Y.; Huang, S.; Xia, X.; Liu, X.; Pan, S.; Jiao, C.; Cheng, W.; Guo, Y.; Zhao, J. *; Shen, J.-W.*, Bimetallic plasmonic nanozyme-based microneedle for synergistic ferroptosis therapy of melanoma. Advanced Science, 2025, 12 (30), e04203(中科院一区TOP期刊,IF=14.1)
5. Liu, X.; Lai, Y.; Gao, Y.; Cheng, W.; Xu, J.; Zeng, J.*; Shen, J.-W.*; Duan, W.*, Dual-functional trimetallic nanozyme with computation-aided interpretation for synergistic degradation and detection of tetracycline antibiotics. Journal of Hazardous Materials, 2025, 499, 140264(中科院一区TOP期刊,IF=11.3)
6. Xia, X.; Liu, X.; Gao, Y.; Lin, J.; Pan, S.; Cheng, W.; Huang, S.; Liu, X.*; Shen, J.-W.*; Duan, W.*, Engineered metallic hybrid nanozyme for advanced inflammatory disease therapy. Materials Today Bio, 2025, 35, 102572(中科院一区TOP期刊,IF=10.2)
7. Duan, W.; Gao, Y.; Xu, R.; Huang, S.; Xia, X.; Zhao, J.; Zeng, L.; Wei, Q.; Shen, J.-W.*; Wu, J.*; Zheng, Y.*, Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing. Materials Today Bio, 2025, 31, 101522(中科院一区TOP期刊,IF=10.2)
8. Guo, G.; Ren, X.; Li, X.; Wu, X.; Qu, C.; Duan, W.*; Zeng, J.*, A three-stage amplified pressure bioassay for sensitive detection of cardiac troponin. Talanta, 2025, 289, 127772(中科院一区TOP期刊,IF=6.1)
9. Dong, M.; Wang, Y.; Cao, L.; Fei, X.; Qian, J.; Wu, Q; Zhou, L; Zhang, Y; Duan, W.*; Zhang, C*; Dou, C.*, Dual enzyme-driven redox homeostasis disruption with ultrasmall Pt-decorated MoS2 for combined ferroptosis therapy of hepatocellular carcinoma. Materials Today Bio, 2025, 34, 102260(中科院一区TOP期刊,IF=10.2)
10. Duan, W.; Zhao, J.; Gao, Y.; Xu, K.; Huang, S.; Zeng, L.; Shen, J.-W.*; Zheng, Y.*; Wu, J.*, Porous silicon-based sensing and delivery platforms for wound management applications. Journal of Controlled Release, 2024, 371, 530-554(中科院一区TOP期刊,IF=11.5)
11. Duan, W.*; Xu, K.; Huang, S.; Gao, Y.; Guo, Y.; Shen, Q.; Wei, Q.; Zheng, W.; Hu, Q.*; Shen, J.-W.*, Nanomaterials-incorporated polymeric microneedles for wound healing applications. International Journal of Pharmaceutics, 2024, 659, 124247(中科院二区TOP期刊,IF=5.2)
12. Liu, X.; Liang, X.; Yu, J.; Xu, K.; Shen, J.-W.*; Duan, W.*; Zeng, J.*, Recent development of noble metal-based bimetallic nanoparticles for colorimetric sensing. Trends in Analytical Chemistry, 2023, 169, 117386(中科院一区TOP期刊,IF=12.0)
13 Duan, W.; Zhao, J.; Liu, X.; Zheng, Y.*; Wu, J.*, Trapping and release of NIR-active dye in porous silicon as a theranostic strategy for ROS photothermal monitoring and chronic wound management. Journal of Controlled Release, 2023, 359, 428-440(中科院一区TOP期刊,IF=11.5)
14. Duan, W.; Wang, J.; Peng, X.; Cao, S.; Shang, J.; Qiu, Z.; Lu, X.*; Zeng, J.*, Rational design of trimetallic AgPt-Fe3O4 nanozyme for catalyst poisoning-mediated CO colorimetric detection. Biosensors and Bioelectronics, 2023, 223, 115022(中科院一区TOP期刊,IF=10.5)
15. Duan, W.; Qiu, Z.; Cao, S.; Guo, Q.; Huang, J.; Xing, J.; Lu, X.; Zeng, J., Pd-Fe3O4 Janus nanozyme with rational design for ultrasensitive colorimetric detection of biothiols. Biosensors and Bioelectronics, 2022, 196, 113724(中科院一区TOP期刊,IF=10.5)
16. Duan, W.; Liu, X.; Zhao, J.; Zheng, Y.*; Wu, J.*, Porous silicon carrier endowed with photothermal and therapeutic effects for synergistic wound disinfection. ACS Applied Materials & Interfaces, 2022, 14, 43, 48368-48383(中科院二区TOP期刊,IF=8.2)
17. Duan, W.; Jin, Y.; Cui, Y.; Xi, F.; Liu, X.; Wo, F.; Wu, J.*, A co-delivery platform for synergistic promotion of angiogenesis based on biodegradable, therapeutic and self-reporting luminescent porous silicon microparticles. Biomaterials, 2021, 272, 120772(中科院一区TOP期刊,IF=12.9)
18. Duan, W.; Liu, A.; Li, Q.; Li, Z.; Wen, C.-y.; Cai, Z.; Tang, S.; Li, X.; Zeng, J.*, Toward ultrasensitive and fast colorimetric detection of indoor formaldehyde across the visible region using cetyltrimethylammonium chloride-capped bone-shaped gold nanorods as “chromophores”. Analyst, 2019, 144, 4582-4588(中科院二区,IF=3.3)
19. Jiao, C.; Duan, W. (co-first); Wu, X.; Shang, Y.; Zhang, F.; Zhang, M.; Chen, X.; Zeng, J.*; Yang, C., Multifunctional nanoprobe amplified ELISA on capillary: a universal platform for simple, rapid and ultrasensitive dual-mode pathogen detection. Analytical Chemistry., 2023, 95, 30, 11316-11325(中科院一区TOP期刊,IF=6.7)
20 Qiu, Z.; Duan, W. (co-first); Cao, S.; Zeng, T.; Zhao, T.; Huang, J.; Lu, X.; Zeng, J*.,Highly specific colorimetric probe for fluoride by triggering the intrinsic catalytic activity of a AgPt–Fe3O4 hybrid nanozyme encapsulated in SiO2 Shells. Environmental Science & Technology, 2022, 56, 3, 1713-1723 (中科院一区TOP期刊,IF=11.3)
21. Cui, Y.; Duan, W. (co-first); Jin, Y.; Wo, F.; Xi, F.; Wu, J.*, Graphene quantum dot-decorated luminescent porous silicon dressing for theranostics of diabetic wounds. Acta Biomaterialia, 2021, 131, 544-554 (中科院一区TOP期刊,IF=9.6)
